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Novartis: Projects

Bristol Myers Squibb, Novartis, and Takeda 

Cell and gene therapies, which hold great promise for the treatment of diseases like cancer and diabetes, are the next wave of life science innovation. Manufacturing these highly customized therapies is a labor-intensive process that requires an extremely high level of learning innovation. With more lab technicians to train than instructors and training labs available, cell and gene therapy leaders Takeda, Novartis, and Bristol Myers Squibb all partnered with the Gronstedt group to custom develop virtual reality (VR) training. Recruits practice crucial life-saving skills in our failsafe, real-time rendered cleanrooms deployed on reality-bending high-quality headsets that cost less than an airline flight.


“We use VR simulators to train cleanroom technicians on aseptic processes, equipment operation, and laboratory manipulations. It’s ushering in a new era of experiential learning that promises to upend recruitment, selection, and training in life science as we know it.” 

Brian Kesselmeyer, Associate Technical Director and Cell Therapy Capability Center Lead at Bristol Myers Squibb


Unlike traditional pharma manufacturing (pills, infusions), cell and gene therapies are made to order. Patient cells or genes must be painstakingly purified and modified for weeks in labs before being injected back into the patient. Mistakes have life-and-death consequences, and every worker is shadowed by a quality reviewer. As much as 25% of CAR T cell therapy expense is driven by labor. Training operators to make these personalized medicines dependably, without taking physical lab space or subject matter experts away from production, is a billion-dollar challenge. One solution: what if we could recreate physical cleanrooms with interactive, photo-realistic digital versions?

Bristol Myers Squibb cell therapy VR cleanroom

Bristol Myers Squibb cell therapy lab techs, working from literally anywhere in the world, don a VR headset and dive into an immersive, high-fidelity cleanroom of such convincing verisimilitude that they feel like they’re actually there.

“They can practice gowning and gloving, sterile tube welding and sealing, first air rule and aseptic practices in a virtual lab. Moving seamlessly from the real to the digital realms, they can build muscle memory before they even put a foot in the training lab.” 

Elissa Hoehn, consultant for the Cell Therapy Capability Center at Bristol Myers Squibb.

The simulation starts in the Learning Level, which is built on step-by-step video tutorials, feedback, and guided practice. Next, students move on to the Practice Level, which mimics the real-life working experience (i.e., no hand holding). Techs can rehearse techniques over and over to hone skills in preparation for their manufacturing qualification in a physical training lab. VR simulations build mastery by offering deliberate practice at the edge of users’ comfort zones. When they get it wrong, the sim resets so they can try that step again. There are unlimited re-dos in the metaverse. 

VR training saves not only trainer and lab time, but also slashes the use of consumables (gowning and personal protective equipment, plastic bags and tubing, media and chemicals) that would otherwise end up in landfills or burned as biohazardous waste.

Takeda’s multi-user simulation

Takeda is piloting a shared virtual cell therapy manufacturing facility for up to eight students and instructors (again, sited anywhere in the world). They can interact seamlessly, talk to each other, and learn with and from each other in the performance environment. Succeeding and failing together, the cohort learns with and from each other in the performance environment and builds trust.

“Multi-user VR simulations elevate the learning experience by providing the sensation of working shoulder-to-shoulder with colleagues, just like in real life. Students can conduct collaborative tasks, handing each other equipment and inspecting each other’s work, for instance.”

Ted Lehman, Associate Director of Takeda Cell Therapy. 

Novartis VR pioneer

Novartis pioneered virtual reality training for its CAR T cell therapy manufacturing five years ago. Hand and body tracking in the sims measure if the students’ hands are angled correctly so as to not interrupt airflow in the biosafety cabinet.

“The sensory experiences of touch, vision, and sound are incredibly convincing. For instance, when users spray their hands with an antiseptic cleaner, both hands feel a slight vibration through the hand controllers and they hear the spray bottle in the headset. The brain suspends disbelief and generates a sense that their hands are actually being sprayed.” 

Steve Sitek, Global Head, Talent & Transformation at Novartis Gene Therapies

It would make Aristotle proud. Educational theorists as far back as the ancient Greece philosopher have pointed out that we cannot learn what we have not experienced. This is a critical time to reimagine life science training around an assumption of constructivist and visceral learning we once could only dream about. Today, Novartis is even developing VR to train manufacturing personnel of another innovative cancer treatment: radiopharmaceutical therapies. Operators practice working in glove boxes with radioactive medication in a safe virtual environment, just like pilots practice flying in a flight simulator.

A VR learning partner

Developing these 3D immersive simulations is a complex and iterative process that marries the artistry and tech wizardry of virtual reality and game development with learning design and subject matter expertise. BMS, Takeda, and Novartis turned to Gronstedt Group to bring their learning vision into the metaverse. We helped identify high-value opportunities, build the business case, overcome obstacles, bring your concepts to (virtual) reality, and scale them across the enterprise with single sign-on and student LMS reporting.

Regulatory pressure 

A third of all therapies are soon expected to be cell- and gene-based. Under pressure from regulators to prove that the products given to patients is the same as the ones tested in clinical trials, the industry needs to invest in completely new manufacturing training models. Traditional new drug reviews focused 80% on clinical and 20% on manufacturing controls, but that proportion is now inverted. Developers must prove that they’re effectively training staff to consistently manufacture these highly customized therapies. Ultra-realistic VR cleanroom simulators are the learning breakthrough that will bring the medical innovations of cell and gene therapies to market. 

Immersive learning is here – it’s just unevenly distributed. Where cell and gene therapies are leading the way, the entire life science industry will follow. Gronstedt Group can help reduce training costs, improve job performance, and boost engagement with a VR “flight simulator” of life science learning.

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